ANTIHISTAMINIQUES H1 PDF

Les urticaires constituent leur indication de choix. Histamine is an inflammation mediator that is fundamental for the development of some allergic reactions and is also implied in several common dermatological affections. Anti-H1s are molecules capable of couteracting the effect of histamine on its specific receptors. There are two types: first generation anti-H1 and second generation anti-H1. A reference search was made using the Pubmed data bank. Critical analysis was made of the articles selected based on their evidence.

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Nearly 40 million Americans have symptoms of upper respiratory allergies, making antihistamines among the most frequently used pharmacologic agents. Although there are mediators of allergic symptoms in addition to histamine, therapy for allergic rhinitis and urticaria has focused upon the use of antihistamines. The classic histamine H1-receptor antagonists, however, are not selective for the H1 site and produce a variety of dopaminergic, serotonergic, and cholinergic responses leading to considerable adverse effects in the central nervous system consequent to both their pharmacologic nonselectivity and their ability to penetrate the blood-brain barrier readily.

The second-generation antihistamines were a major advance in the therapy of allergic rhinitis, because they do not penetrate the blood-brain barrier as rapidly and are also designed for greater specificity at H1-receptor. Given their greater selectivity for the H1-receptor, they cause fewer undesirable central nervous system actions, whereas their efficacy is similar to that of the classic antihistamines used in the treatment of allergic rhinitis.

Selecting among these antihistamines for the treatment of allergic rhinitis has focused on their pharmacokinetics and adverse effect profiles. The potential cardiotoxic effects of some antihistamines when their metabolism is inhibited requires caution in prescribing these agents.

The antiallergic and antiasthmatic effects of several newer antihistamines are being explored. For the clinician, making the therapeutic decision among H1-receptor antagonists requires a comprehensive knowledge of their diverse effects.

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Kalpaklioglu F, Baccioglu A. Kalpaklioglu F, et al. Antiinflamm Antiallergy Agents Med Chem. PMID: Review. Nonsedating antihistamines: pharmacology, clinical efficacy and adverse effects. Kaliner MA. Am Fam Physician. H1-antihistamines in the elderly.

Clin Allergy Immunol. Cetirizine: antiallergic therapy beyond traditional H1 antihistamines. Sheffer AL, et al. J Allergy Clin Immunol. Riechelmann H. Show more similar articles See all similar articles. Matsui S, et al. J Invest Dermatol.

Epub Jul PMID: Efficacy and tolerability comparison of ebastine 10 and 20mg with loratadine 10mg: a double-blind, randomised study in patients with perennial allergic rhinitis. Davies RJ, et al. Clin Drug Investig. Selecting the optimal oral antihistamine for patients with allergic rhinitis. Lehman JM, et al. Synergistic action of famotidine and chlorpheniramine on acetic acid-induced chronic gastric ulcer in rats. Qin Z, Chen C.

Qin Z, et al. World J Gastroenterol. Cost-benefit analysis of first-generation antihistamines in the treatment of allergic rhinitis. Sullivan PW, et al. Show more "Cited by" articles See all "Cited by" articles. Publication types Comparative Study Actions. Review Actions. Humans Actions. Substances Histamine H1 Antagonists Actions. Full-text links [x] Elsevier Science. Copy Download.

ASTM D4020 PDF

Clinical Comparison of Histamine H1-receptor Antagonist Drugs

Nearly 40 million Americans have symptoms of upper respiratory allergies, making antihistamines among the most frequently used pharmacologic agents. Although there are mediators of allergic symptoms in addition to histamine, therapy for allergic rhinitis and urticaria has focused upon the use of antihistamines. The classic histamine H1-receptor antagonists, however, are not selective for the H1 site and produce a variety of dopaminergic, serotonergic, and cholinergic responses leading to considerable adverse effects in the central nervous system consequent to both their pharmacologic nonselectivity and their ability to penetrate the blood-brain barrier readily. The second-generation antihistamines were a major advance in the therapy of allergic rhinitis, because they do not penetrate the blood-brain barrier as rapidly and are also designed for greater specificity at H1-receptor.

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