The Starling equation for fluid filtration is named for the British physiologist Ernest Starling , who is also recognised for the Frank—Starling law of the heart. The classic Starling equation has in recent years been revised. The Starling principle of fluid exchange is key to understanding how plasma fluid solvent within the bloodstream intravascular fluid moves to the space outside the bloodstream extravascular space. Starling can be credited with identifying that the "absorption of isotonic salt solutions from the extravascular space by the blood vessels is determined by this osmotic pressure of the serum proteins. Transendothelial fluid exchange occurs predominantly in the capillaries, and is a process of plasma ultrafiltration across a semi-permeable membrane. Where the endothelial glycocalyx overlies an inter endothelial cell cleft, the plasma ultrafiltrate may pass to the interstitial space.
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