FUNDAMENTALS OF BIOMEMS AND MEDICAL MICRODEVICES PDF

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BioMEMS devices are as important to the future of medicine as microprocessors were to the computer revolution at the end of the last century. BioMEMS is a science that includes more than simply finding biomedical applications for microelectromechanical systems devices.

It represents an expansion into a host of new polymer materials, microfluidic physics, surface chemistries and their modification, "soft" fabrication techniques, biocompatibility, and cost-effective solutions to biomedical problems. It brings together the creative talents of electrical, mechanical, optical, and chemical engineers, materials specialists, clinical laboratory scientists, and physicians. BioMEMS devices are the platform upon which nanomedicine will be delivered.

Based on the author's course on bioMEMS at the University of Minnesota, this book is an introduction to the science and a survey of the state of the art. Topics include microfabrication of silicon, glass, and polymer devices; microfluidics and electrokinetics; sensors, actuators, and drug-delivery systems; micro-total-analysis systems and lab-on-a-chip devices; detection and measuring systems; genomics, proteomics, DNA, and protein microarrays; emerging applications in medicine, research, and homeland security; and packaging, biocompatibility, and ISO testing.

The first text of its kind dedicated to bioMEMS training, this book is suitable for a single semester course for senior and graduate-level students, or as an introduction to others interested or already working in the field.

BioMEMS stands for biomedical microelectromechanical systems. Although perhaps not an ideal term, since electromechanical evokes an image of electrically driven coils, solenoids, and machined parts, it has caught on to encompass some of the most interesting new technologies today. It is a matter of perspective, for micro places us in a new realm altogether, and allows us to conceptualize electromechanical as any physical, electrochemical, biochemical, or fluidic phenomenon that accomplishes work at the microscale.

This work includes microsensing, microactuation, microassaying, micromoving, and microdelivery. BioMEMS devices are the platform upon which nanomedicine will be delivered for the betterment of the human condition. It is also the quintessential science for genomics, the study of sets of genes, gene products, and their interactions; and proteomics, the study of proteins, the expression of genes in health and disease.

Designing, modeling, and fabricating medical microdevices will increase enormously in the next ten years, and the need for people involved in this activity to communicate their ideas, needs, and capabilities requires specialized training that bridges diverse backgrounds, and introduces the terminology and potential of the field.

It is necessary for the medical community to take a serious look at including bioMEMS and medical microdevices as prerequisite training for entry into medical school, as a research elective during medical training or as part of a combined M.

There are innumerable medical problems that can be solved with these devices, but there exists a shortage of medical specialists in the field. It is also prudent for the biomedical engineering community to consider holding medical case presentations to become more aware of medicine and design opportunities. Hospitals and large clinics in the future may need to employ biomedical engineering doctorates in device management much as they employ doctorates in pharmacy.

This specialization seems inevitable as I have witnessed advances in pacemakers and implantable defibrillators, insulin pumps, and other devices beyond the knowledge base of primary care physicians.

There will be an explosion of new implantable devices based on bioMEMS technology, and it is foreseeable that new standards will emerge, governing interconnectivity, power, and data telemetry so that all implantable devices will have conforming features. This will allow small companies to enter the market and focus on one or more aspects of more complex systems.

United States and foreign patents help recoup investments in bioMEMS devices by allowing a company to develop, manufacture, and market a new device, or license the technology as they see fit. Investors must be aware that the road for a newly patented device to market is a difficult and expensive journey not unlike the development of a new medication. There may be biocompatibility issues to resolve, clinical trials to perform, and Federal Drug Administration FDA requirements to satisfy.

In the end someone will need to pay for the new technology, including facilities that buy bioMEMS-based equipment, and the patients who require evaluation and therapy. New devices intended for medical care will require advocacy from the medical community and demonstration of superiority over existing methods. This book is the first dedicated to bioMEMS and medical microdevice training, and is suitable for a single semester course for upper senior and graduate students, or as an introduction to others interested or already working in the field.

Topics include 1 microfabrication of silicon, glass, and polymer devices; 2 microfluidics and electrokinetics; 3 sensors, actuators, and drug-delivery systems; 4 micro-total- analysis-systems mTAS and lab-on-a-chip devices LOC ; 5 an introduction to clinical laboratory medicine; 6 detection and measuring systems; 7 genomics, proteomics, DNA, and protein microarrays; 8 emerging applications in medicine, research, and homeland security; 9 packaging, power systems, data communication, and RF safety; and 10 biocompatibility, FDA guidance, and ISO biological evaluations.

The book is written to appeal to the diversity of training and background of its readers, and includes introductory material, advanced concepts, and current research. The foundations for conceiving, designing, and applying bioMEMS and medical microdevices at both the research and clinical level are addressed. An extensive glossary covers both the engineering and healthcare terminology.

I am very appreciative of the staff at SPIE, including its editorial staff and reviewers, and of all the others who made this book possible. I am also grateful to my students and colleagues, and for the opportunity to lecture on this subject in the Department of Biomedical Engineering at the University of Minnesota, under the leadership of Robert Tranquillo.

There are many individuals who through the years have provided me with the necessary background and inspiration to complete this book, and I would like to express my sincere gratitude.

I would also like to thank the many authors and investigators whose works I have relied on in completing this book. Comments and suggestion for future editions are always welcome. Instructors at educational institutions may inquire about Power Point presentations by sending me an e- mail.

I have prepared about slides divided into 18 lectures, suitable as an introductory course when used in conjunction with the book. Steven S. Sign In View Cart 0 Help. Share Email Print. Sample Pages. Add to cart. Book Description. Table of Contents.

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Bringing together the creative talents of electrical, mechanical, optical and chemical engineers, materials specialists, clinical-laboratory scientists, and physicians, the science of biomedical microelectromechanical systems bioMEMS promises to deliver sensitive, selective, fast, low cost, less invasive, and more robust methods for diagnostics, individualized treatment, and novel drug delivery. This book is an introduction to this multidisciplinary technology and the current state of micromedical devices in use today. The first text of its kind dedicated to bioMEMS training. Fundamentals of BioMEMS and Medical Microdevices is Suitable for a single semester course for senior and graduate-level students, or as an introduction to others interested or already working in the field. Steven Saliterman.

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Fundamentals of BioMEMS and Medical Microdevices

Steven S. His research is in optical and microwave applications of bioMEMS. His interest also include electrical and mechanical engineering, computer design, and software development. His early work in computer design received achievement awards from the Professional Engineers Society of Minnesota and the United States Army. He has designed and patented a system for simulating critical care patient management, inclusive of a manikin apparatus for practicing heart catheterization.

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Steven Saliterman. BioMEMS devices are as important to the future of medicine as microprocessors were to the computer revolution at the end of the last century. BioMEMS is a science that includes more than simply finding biomedical applications for microelectromechanical systems devices. It represents an expansion into a host of new polymer materials, microfluidic physics, surface chemistries and their modification, soft fabrication techniques, biocompatibility, and cost-effective solutions to biomedical problems.

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